Mapping the β-Scorpion Toxin Receptor Site on Voltage-Gated Sodium Channels
نویسندگان
چکیده
منابع مشابه
Voltage-Gated Sodium Channels Modulation by Bothutous Schach Scorpion Venom
Buthotus schach is one of the dangers scorpion in Iran that belong to the Buthidae family. Toxins are existing in venom scorpion, modulate the ion channels by blocking or opening the pore of the channel or by altering the voltage gating and useful as pharmacological tools. In the present study, we investigated the effect of venom and its obtained fractions by gel filtrations on electrophysiolog...
متن کاملvoltage-gated sodium channels modulation by bothutous schach scorpion venom
buthotus schach is one of the dangers scorpion in iran that belong to the buthidae family. toxins are existing in venom scorpion, modulate the ion channels by blocking or opening the pore of the channel or by altering the voltage gating and useful as pharmacological tools. in the present study, we investigated the effect of venom and its obtained fractions by gel filtrations on electrophysiolog...
متن کاملVoltage Sensor of Sodium Channels Probed by a β-Scorpion Toxin
Voltage sensing by voltage-gated sodium channels determines the electrical excitability of cells, but the molecular mechanism is unknown. ß-scorpion toxins bind specifically to neurotoxin receptor site 4 and induce a negative shift in the voltage dependence of activation through a voltagesensor trapping mechanism. Kinetic analysis showed that β-scorpion toxin binds to the resting state and subs...
متن کاملMapping the interaction site for a β-scorpion toxin in the pore module of domain III of voltage-gated Na(+) channels.
Activation of voltage-gated sodium (Na(v)) channels initiates and propagates action potentials in electrically excitable cells. β-Scorpion toxins, including toxin IV from Centruroides suffusus suffusus (CssIV), enhance activation of Na(V) channels. CssIV stabilizes the voltage sensor in domain II in its activated state via a voltage-sensor trapping mechanism. Amino acid residues required for th...
متن کاملVOLTAGE-GATED ION CHANNELS Voltage-Gated Sodium Channels
Antiepileptic drugs (AEDs) protect against seizures through interactions with a variety of cellular targets. By affecting the functional activity of these targets, AEDs suppress abnormal hypersynchronous activity in brain circuits, leading to protection against seizures. The actions on these targets can be categorized into four broad groups: (i) modulation of voltage-gated ion channels, includi...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2010
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2009.12.603